Loss of Prefrontal Cortical Higher Cognition with Uncontrollable Stress (2019)

This article discusses the effects of uncontrollable stress on the prefrontal cortex (PFC) and its role in regulating behavior, thought, and emotion. The authors review the molecular mechanisms underlying the PFC's vulnerability to stress and how it can lead to changes in brain function and structure, including dendritic atrophy and loss of spines.